When I see a dome of red terracotta tiles with white ribs, I think of Brunelleschi’s dome in Florence. However, I understand that this represents the biblical first city, founded by Cain, so it was likely freely imagined by the artist, even though they certainly drew inspiration from real, individual buildings (on the right, You are not allowed to view links.
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Login to view., 1450 ca). The dome in Florence was built between 1420 and 1436, so maybe it's too late to have inspired the manuscript?