I definitely agree with Koen - it's certainly
possible that the hand crossing the fold implies that the leaves are both conjoint and consecutive, but it's a harder case to make than with 78v/81r.
I'm currently working on the question of the original sequence of ALL of the bifolia in the manuscript, in collaboration with others and using several different methodologies:
Codicological evidence: As in the present thread and in my blog: You are not allowed to view links.
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Topic modeling: Does this kind of linguistic analytics result in a stronger association of, for example, 81r with 78v rather than 80v?
Image analytics: Using AI analytics to model how the waterstain at the beginning of the manuscript should flow through those first quires, potentially allowing for the establishment of the correct quire structure in the herbal section.
More MSI: using UV imaging to look for offsets that aren't necessarily visible to the naked eye - one example is demonstrated in my recent blogpost <You are not allowed to view links.
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These are complex and lengthy investigations that have required the development of several new computational and investigative models. I hope to have some results to share in the coming months.