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MichelleL11 · 09-01-2022, 02:54 AM

(08-01-2022, 11:22 PM)Bernd wrote: You are not allowed to view links. Register or Login to view.My question - assuming DNA fragments from multiple humans are isolated, what are the current limits of sorting and using them for SNP analysis? Has this been tested? Next Gen Sequencing already is extremely challenging for microorganisms in environmental samples but at least these are highly dissimilar compared to humans.

Hi, Bernd:
I think this question has more in common with forensic analysis than biocodicology at this point. Thus, l would start with this very recent review about DNA mixture analysis:

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I did find software-based detection that differentiated contaminating modern DNA from “ancient DNA” based on amount of degradation- but in that publication they were talking about human ancestor species vs modern - so 10,000s of years. I didn’t get the impression that it was sensitive enough to see a 600 year gap - or would ever be able to tell as enough differences may not exist as to that particular change (the same deanimation process discussed in the York Gospels article).

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But something may be developed in the future on some kind of differentiation basis other than primary sequence (e.g. SNPs).