I would add following information
- a variant of substitution cipher is
nomenclator cipher. A nomenclator is a list of codewords for commonly used names, locations, phrases, etc. I have never seen a cipher that would be 100% codewords but mixing regular substitution with codewords was common. Such ciphers usually had many different symbols so what we have in VM is rather something different
- another trick in substitution ciphers are single signs coding syllables/groups of letters
- it can be also the opposite way, a substitution cipher may be "verbose" and I mean here that several symbols are coding a single letter. We have a well known example of such cipher, known since antiquity Polybius Square:
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- in advanced substitution ciphers there may be many other tricks like "a sign which means to ignore the previous sign" or so. But they are probably younger than Voynich Manuscript