There is evidence suggesting it was written over a period of time, perhaps even decades. If the author is not a wealthy man, and it is a private project, it may have been compiled as finance permitted. Different scribes were employed at different times for different sections, and importantly, the text system seems to change ('evolve") which suggests refinements made over time. The binding came later.
How uniform is the vellum? I don't know. All the same source and same age? How old was it when the ink was applied? (Probably not too old.)
I'm inclined, anyway, to a later beginning within the window, largely because I think the work reflects East/West encounters and probably depends upon the Neoplatonism of Plethon and becomes more likely as efforts to reconcile the Greek and Latin worlds increase in the decades leading up to the Fall of Byzantium. The historical and intellectual milieu of the later 1420s and 1430s seems more likely to me. After the first seige of Constantinople in the 1420s.
How uniform is the vellum? I don't know. All the same source and same age? How old was it when the ink was applied? (Probably not too old.)
I'm inclined, anyway, to a later beginning within the window, largely because I think the work reflects East/West encounters and probably depends upon the Neoplatonism of Plethon and becomes more likely as efforts to reconcile the Greek and Latin worlds increase in the decades leading up to the Fall of Byzantium. The historical and intellectual milieu of the later 1420s and 1430s seems more likely to me. After the first seige of Constantinople in the 1420s.


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