The Voynich Ninja

This is something I find very intriguing, but I think we'll never know the answer. So this is a purely speculative thread. 

Is there any part of the time line we know for sure? 
And if we speculate, what are some likely ways the MS could have ended up in Prague? Which areas has it likely travelled through?
And how come that not even two centuries after its creation people didn't have any idea about its provenance?